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Benzathine benzylpenicillin can be eliminated by hemodialysis. No data are available on the influence of dialysis on plasma levels of benzyl penicillin. Therefore, the decision to treat dialysis patients with Benzethacycil should be made on a case-by-case basis.
For depot preparations, although it is recommended not to administer more than 5 ml per injection site as a tolerance limit, the entire vial can be administered at one site. In case of excessive pain, the volume can be divided in two injection sites.
Before initiating therapy with BENZETACIL, a careful investigation of previous hypersensitivity reactions to penicillins, cephalosporins or other beta-lactam agents should be performed (see sections 4.3 and 4.8).
Severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS) and acute generalized exanthematous pustulosis (AGEP), have been reported in association with treatment with beta-lactam antibiotics (including penicillins).
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A hypersensitivity test should be performed if possible before treatment. If an allergic reaction occurs, your doctor will stop your treatment and if necessary, appropriate treatment will be started.
If you are asthmatic or allergic to hay fever, inform your doctor. Immediate severe allergic reactions are possible when treatment is first given. In some cases, you may be kept under observation for at least half an hour after administration of the drug in case of acute allergic reaction. In case of allergy, the physician will take appropriate measures. Treatment with BENZETACIL 1,200,000 IU should be discontinued immediately.
When treating syphilis, a reaction of the organism to bacterial toxins may occur, lasting up to several days (Jarisch-Herxheimer reaction, see section 4). Symptoms are sudden fever (sometimes with chills), pallor, followed by reddening of the skin, headache, muscle and joint pain or fatigue. Your physician will initiate appropriate treatment to suppress or attenuate a Jarisch-Herxheimer reaction.
1. LAS CONTINUAS LLUVIAS HAN PROVOCADO GRAVES INUNDACIONES Y NUMEROSOS DESLIZAMIENTOS DE TIERRA EN EL ESTADO DE RÍO DE JANEIRO. EL REPRESENTANTE RESIDENTE DEL UNDRO/UNDP HA ESTADO EN CONTACTO CON EL MINISTERIO DEL INTERIOR, DEFENSA CIVIL Y OTROS CANALES, Y JUNTO CON OTRAS INFORMACIONES RECIBIDAS POR EL UNDRO, SE INFORMA DE LAS SIGUIENTES CONSECUENCIAS GRAVES:
2. LAS CONEXIONES POR CARRETERA CON LA CIUDAD DE PETRÓPOLIS ESTABAN COMPLETAMENTE CORTADAS, LO QUE DIFICULTA LAS OPERACIONES DE SOCORRO Y LA EVALUACIÓN DE LOS DAÑOS. LOS ÚLTIMOS INFORMES INDICAN QUE YA SE HAN RESTABLECIDO. SE TEME QUE UNAS 300 PERSONAS HAYAN MUERTO Y QUE HAYA NUMEROSOS HERIDOS. APROXIMADAMENTE 6.000 PERSONAS SE HAN QUEDADO SIN HOGAR, CON 1.000 CASAS DESTRUIDAS O INHABITABLES EN LAS REGIONES DE CAXIAS, NOVA IGUACU, PETROPOLIS Y TERESOPOLIS.
3. EL PRESIDENTE JOSE SARNEY HA PUESTO A DISPOSICIÓN 100 MILLONES DE CRUZADOS PARA AYUDAR A LAS VÍCTIMAS A TRAVÉS DEL INSTITUTO BRASILEÑO DE ASISTENCIA (LBA). LA CRUZ ROJA BRASILEÑA PARTICIPA ACTIVAMENTE EN LAS LABORES DE RESCATE Y EN EL SUMINISTRO DE AYUDA.
1. CONTINÚAN LAS FUERTES LLUVIAS, Y SIGUE EXISTIENDO EL PELIGRO DE DESPRENDIMIENTOS EN VARIAS ZONAS. LAS CIUDADES MAS AFECTADAS SON PETROPOLIS, TERESOPOLIS, S.J. DO MERITI, NOVA IGUACU, DUQUE DE CAXIAS, NILOPOLIS, C. DE MACACU Y RIO DE JANEIRO. SE HAN CONFIRMADO 178 MUERTOS Y 617 HERIDOS, MIENTRAS QUE 8.376 PERSONAS SIN HOGAR SE HAN REFUGIADO EN EDIFICIOS PÚBLICOS, ESCUELAS O TIENDAS DE CAMPAÑA.
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THERAPEUTIC INDICATIONS: BENZATIN BENCYLPENICILLIN is indicated in the treatment of infections caused by penicillin-susceptible bacteria, therapy should be guided by bacteriological studies and by the clinical response of the patient. Streptococcal infections (group A without septicemia).Upper respiratory tract infections (such as pharyngitis, tonsillitis).Venereal infections such as syphilis and gonorrhea.As a prophylactic to prevent the development of glomerulonephritis and rheumatic fever by eradication of group A beta hemolytic streptococcus.
CONTRAINDICATIONS: History or reaction of previous hypersensitivity to any type of penicillin or cephalosporin, as well as angioneurotic edema, serum sickness and interstitial nephritis.
RESTRICTIONS ON USE DURING PREGNANCY AND BREASTFEEDING: To date, no alterations have been reported in humans during pregnancy; since penicillin is excreted in breast milk, it may cause sensitization and skin rash in the infant.