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Methods: Double-blind, controlled, multicenter, randomized, controlled study. Group 1 was given thiocolchicoside, diclofenac and B vitamins and group 2, diclofenac and B vitamins. The dose was 1 tablet every 12 hours for 48 hours. Evaluations: Evolution of pain, degree of pain relief, contracture and functionability, toe-floor distance, overall physician and patient satisfaction, need for continuity of treatment and adverse reactions.

Results: 148 patients were analyzed: 74 in group 1 and 74 in group 2. The decrease and degree of pain relief, contracture reduction and overall patient and researcher satisfaction were statistically significant in favor of group 1. The evaluation of function and mobility in low back pain was better in group 1, with no statistically significant difference. At 48 hours, 93.2% of group 1 and 79.2% of group 2 stopped treatment due to sufficient pain relief. Adverse reactions were minimal in both groups.

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Often, the first symptoms of a gout attack are sudden pain and swelling in one of the joints. The joint most often affected is the big toe, but gout can occur in any joint (such as ankles, knees, elbows or fingers). The joint may feel warm to the touch. The skin around the joint may be red.

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The exact cause of gout is not known. But certain factors may increase your risk of getting gout. You are more likely to have gout if others in your family have had it. Also, being overweight can increase your risk of gout.

Your health care professional will talk with you about your symptoms. However, it can be hard to tell if a person has gout based on symptoms alone. Other types of arthritis can cause similar symptoms.

Ideally, a gout attack should begin to be treated within 24 hours of the onset of symptoms. Your health care professional may suggest a medication to reduce pain and swelling. This medication may be:

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The Australian Neuromuscular Disease Registry (ANMDR) is an Australia-wide registry of people diagnosed with a neuromuscular disease. It collects important medical information from adult and child patients across the country to improve the understanding of neuromuscular disease and accelerate the development of new therapies.

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Advantages and Disadvantages of Analgesics

Diclofenac sodium is a prescription drug used to relieve pain and swelling. It is a non-steroidal anti-inflammatory drug (NSAID). Diclofenac sodium overdose occurs when someone takes

Taking too much diclofenac sodium does not usually cause serious problems. The person may have some stomach pain and vomiting (possibly with blood). However, these symptoms will probably get better. On rare occasions, a blood transfusion may be needed. A tube may need to be inserted through the mouth and into the stomach (endoscopy) to stop internal bleeding.Alternative Names

Aronson JK. Non-steroidal anti-inflammatory drugs (NSAIDs). In: Aronson JK, ed. Meyler’s Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:236-272.Chitturi S, Teoh NC, Farrell GC. Liver disease caused by drugs. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 88.Hatten BW. Aspirin and nonsteroidal agents. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen’s Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 144.

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